KINTAI mainly manufactures 98% Andrographolide, the main ingredient in Andrographis paniculata leaf extract, which is derived from Andrographis paniculata leaves. 

 

Specification		Appearance	Test method	Application
Andrographolide	98%	White powder	HPLC/UV	Pharmaceutical additive
	50%	Brown yellow powder	HPLC
	20%	Brown powder	HPLC
	10%	Brown powder	HPLC

 

Andrographis paniculata leaf extract, also known as Andrographis extract, is an herbal extract obtained from Andrographis paniculata leaves. Andrographis paniculata leaf is the leaf part of Andrographis paniculata plant, whose main components are volatile oil, flavonoids and triterpenoids, etc. It is effective in clearing heat and detoxifying, reducing swelling and pain, anti-inflammatory and analgesic, and enhancing immunity. Andrographis paniculata leaf extract is commonly used in traditional Chinese medicine formulations for the treatment of colds, coughs, asthma, bronchitis, hepatitis, diabetes, and other diseases. Meanwhile, Andrographis paniculata leaf extract is also widely used in food, health care products, beauty and skin care.

 

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No	product name	Specification	CAS.NO	Test Method
1	Andrographis paniculata extract	10%-98%andrographolide	5508-58-7	HPLC
2		25%-98%chlorogenic acid	327-97-9	HPLC
3		50%-98%tea polyphenols	989-51-5	HPLC
4	Soybean Extract	20%-90%soy isoflavones	574-12-9	HPLC
5	Black Sesame Extract	20%-98%sesamin	607-80-7	HPLC
6		5% Monacolin K	21516-68-7	HPLC
7		95%proanthocyanidins	84929-27-1	HPLC
8	Ganoderma lucidum polysaccharide	50%-90%Ganoderma lucidum polysaccharide	/	HPLC
9	Lycium barbarum polysaccharide	50%-90%wolfberry polysaccharide	/	HPLC
10		98%Oleanolic AcidÂ	508-02-1	HPLC
Â		10-98%maslinic acid	4373-41-5	HPLC
Â		10-98%Hydroxytyrosol	10597-60-1	HPLC
Â		40%,70%Oleuropein	32619-42-4	HPLC
11		5%-98%Lycopene, water-soluble lycopene	502-65-8	HPLC
12		98%Luteolin	491-70-3	HPLC
13		30%-90%Mulberry leaf polysaccharide	/	HPLC
Â		1%-20%Mulberry alkaloid 1-deoxynojirimycin (DNJ)	19130-96-2	HPLC
14	Yeast beta-glucan	70%-80%Yeast beta-glucan	9051-09-2	HPLC

 

Andrographis is a perennial herb belonging to the genus Andrographis in the lily family. With its lightly scented flowers, Andrographis is widely used as an ornamental plant in yards and gardens because of its form and aromatic nature. Besides being used as an ornamental plant, Andrographis is also an important medicinal plant. Andrographis is rich in saponins, the most important of which is Andrographis saponin, which can be extracted to make Andrographolide, a powerful cardiac glycoside. KINTAI selects high-quality Andrographis for the manufacturing of 98% Andrographolide.

 

KINTAI's criteria for selecting Andrographis raw materials:

1. Choose fresh andrographis: Fresh andrographis leaves are bright green, with a lubricated surface, bright green and lustrous, soft texture and no yellowing or dryness. This fresh andrographis usually contains a higher content of andrographolides.

2. No obvious wounds in appearance: Pick Andrographis without obvious wounds, pests, etc. This will ensure the purity of the extracted Andrographis andrographolides.

3. Selecting well-grown andrographis: It is more appropriate to select andrographis that are grown in a good ecological environment for andrographolide extraction. This is because these Andrographis will absorb more nutrients and water as they grow, and will also produce more andrographolides in the sun.

4. Use Andrographis with intact stems and leaves: intact stems and leaves indicate that Andrographis is growing well and that they have a higher andrographolide content.

5. Choose andrographis of the same origin and from the same batch: ensure the homogeneity of the andrographis in order to extract a purer andrographolide.

 

CAS Number	5508-58-7	Molecular Weight	350.449
Density	1.2±0.1 g/cm3	Boiling Point	557.3±50.0 °C at 760 mmHg
Molecular Formula	C20H30O5	Melting Point	229-232ºC
Common Name	Andrographolide	Flash Point	195.5±23.6 °C

 

 

Figure 1: HPLC Chromatogram of andrographolide standard . The mobile phase was methanol-water (50:50 v/v). Detection UV 254 nm.

 

7.1. Antioxidant

Andrographolide has powerful antioxidant properties that neutralize free radicals, reducing oxidative cellular damage and protecting the body from chronic disease and aging.

7.2. Anti-inflammatory

Andrographolide helps reduce the body's inflammatory response, which can reduce joint pain, reduce inflammation-related diseases such as atherosclerosis.

Reference:https://www.sciencedirect.com/science/article/abs/pii/S0006295217301880

7.3. Improves cardiovascular health

Andrographolide is believed to improve cardiovascular health by lowering blood pressure and lowering cholesterol and triglyceride levels.

7.4. Improves immune function

Andrographolide may help boost the body's immune function and improve the body's resistance to disease.

7.5. Improves memory and cognitive performance

Andrographolide is believed to improve memory and cognitive performance by helping to protect and stimulate neuronal growth.

7.6. Enhance myocardial contraction

Andrographolide enhances myocardial contraction, resulting in an increase in the heart's ability to pump blood, thus improving cardiac function.

Reference:https://www.ijbs.com/v16p0012.htm

7.7. Control arrhythmias

Andrographolide can regulate the heart rhythm and has a therapeutic effect on arrhythmias such as atrial fibrillation and ventricular fibrillation.

7.8. Reduce the burden on the heart

Andrographolide can reduce the burden on the heart, promote the recovery and improvement of the heart, and facilitate the rehabilitation and treatment of cardiovascular diseases.

7.9. Increase heart endurance

Andrographolide can increase the resistance to stress when the heart is under load, making the heart more resistant to various stresses, which is beneficial to the prevention and treatment of cardiovascular diseases.

8.1. Cerebrovascular diseases: Andrographolide is an effective neuroprotective agent for the prevention and treatment of cerebrovascular diseases (e.g. cerebrovascular lesions, cerebral hemorrhage, etc.), promoting the regeneration of nerve cells, protecting nerve cells from damage caused by oxidative stress, and reducing neuroinflammatory responses.

8.2. Hearing impairment: Andrographolide can promote the regeneration and repair of inner ear hair cells to restore hearing function in patients with hearing impairment.

8.3. Alzheimer's disease: Andrographolide has the effect of improving Alzheimer's disease by promoting the regeneration and recovery of nerve cells and improving the metabolic level and energy metabolism of brain cells.

8.4. Cardiovascular disease: Andrographis paniculata lactone can regulate blood lipid and blood sugar levels, lower blood pressure, and have a preventive and therapeutic effect on cardiovascular disease.

8.5. Other aspects: Andrographolide can also be used to treat hepatitis, liver cirrhosis, rheumatoid arthritis, diabetes, vitiligo and many other diseases.

KINTAI is committed to being your best Andrographis Paniculata Leaf Extract supplier, please feel free to contact us at  or feedback on the next page.

http://www.kintai-bio.com/